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Will New Research Lead to More Effective Ways to Treat Depression?

Published December 8, 2017

It’s said that doing the same thing over and over and expecting different results is the definition of insanity. Does that mean doctors who prescribe one antidepressant after another with no improvement for their patients are crazy? Or does it mean they just don’t have better options? The disturbing fact is, around two-thirds of patients don’t respond to the first antidepressant prescribed. So what happens? They’re prescribed another…and another. Many try as many as four different drugs with no relief from symptoms. The thing is, pinpointing the true cause of depression is difficult. The most commonly prescribed antidepressants―selective serotonin reuptake inhibitors, or SSRIs―are based on the belief that depression is due to a serotonin deficiency in the brain. But what does it tell us when increasing serotonin levels doesn’t work? New research has identified a potential alternative cause of depression that may open more promising pathways for effective treatment. Read more…

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